A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

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A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

Dendritic cells (DCs) are professional antigen-presenting cells with antigen recognition molecules on the surface. Clec9a is selectively expressed on mouse CD8a+ DCs and CD103+ DCs subsets, which are functionally similar to human BDCA3+ DCs. It is reported that Clec9a is responsible for the antigen cross-presentation of these DC subsets. In the present study, by using phage display technique, w...

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Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

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1 Mater Research Institute, University of Queensland, Brisbane, QLD, Australia 2 School of Medicine, University of Queensland, Brisbane, QLD, Australia 3 Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia 4 Department of Immunology, Monash University, Melbourne, VIC, Australia 5 School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia *Correspon...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2016

ISSN: 1949-2553

DOI: 10.18632/oncotarget.9624